Scientists keep pig kidney working in human body for 61 days
Scientists keep pig kidney working in human body for 61 days
Summary
A genetically modified pig kidney worked inside a 57‑year‑old brain‑dead man for 61 days — the longest such survival to date. The pig’s thymus was transplanted too, which helped delay rejection.
Timeline & Events
Transplant: 14 July 2023. Kidney produced urine immediately. On day 33 antibody damage appeared and was treated. Later inflammatory rejection was treated and kidney function recovered. Study ended at day 61.
Treatments used
Plasma exchange, steroids, pegcetacoplan (blocks immune tagging), and a T‑cell depleting drug. These combined stopped rejection and restored function.
Immune findings
Blood analysis showed increased genes linked to rejection (e.g., CXCL9/10/11) and high macrophages and natural killer cells. T cells seem more important than previously thought.
Significance
Shows key treatments can reverse rejection and suggests fewer genetic edits (removal of alpha‑gal) may suffice to prevent immediate rejection. More trials in living patients are required before clinical use.
